Lost every IS key?
No IS key at all means the immobilizer is reset and a new key enrolled, with the blade cut from the VIN-linked key code. The spare price plus $60 applies: $209 for an IS 300 and $349 for any smart-key IS from 2006 on, emergency blade included.
If you drive an IS F or an IS C, say so when you call. Both stayed on the older body past the 2014 redesign, so the year on the registration is not enough to pick the fob. The VIN is, and that registration or title needs a matching license beside it at the car.